22nd Annual Needham Virtual Healthcare Conference
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Cabaletta Bio is a clinical-stage biotechnology company focused on the discovery and development of engineered T cell therapies for autoimmune diseases. Our proprietary Cabaletta Approach to B cell Ablation (CABA™) platform is designed to provide deep, durable and potentially curative responses with one-time administration, with the possibility of eliminating the need for chronic immune suppressive therapies. The CABA™ platform has potential applicability across dozens of B cell-mediated autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, myositis, systemic sclerosis, pemphigus vulgaris and myasthenia gravis. It encompasses both the Chimeric Antigen Receptor T cells for Autoimmunity (CARTA) approach as well as Cabaletta’s proprietary Chimeric AutoAntibody Receptor T (CAART) cells. Our lead CARTA candidate, CABA-201, is a 4-1BB-containing CD19-CAR T cell therapy based on a clinically evaluated fully human CD19 binder with a strong safety profile. CABA-201 is currently under development for autoimmune diseases with high unmet need. Our proprietary CAART cells are designed to selectively bind and eliminate the pathogenic B cells that express disease-causing autoantibodies while sparing normal B cells. Through our CABA™ platform, we have discovered and developed seven product candidates, including our clinical-stage therapies for patients with mucosal pemphigus vulgaris and MuSK myasthenia gravis. We hold multiple agreements with the University of Pennsylvania and other academic institutions to develop engineered T cell therapies. Our goal is to leverage our team’s expertise in autoimmunity and T cell therapy and our network of collaborators to rapidly discover and develop our portfolio of engineered T cell therapy candidates to transform the treatment of autoimmune diseases.
Cabaletta Bio, Inc.
2929 Arch Street
Suite 600
Philadelphia, PA 19104
Anup Marda
Chief Financial Officer
investors@cabalettabio.com
Stern Investor Relations, Inc.
Sarah McCabe
sarah.mccabe@sternir.com
American Stock Transfer & Trust Company, LLC
6201 15th Avenue
Brooklyn, NY 11219
T: 718-921-8200 x4801
help@astfinancial.com
www.astfinancial.com