Cell Therapy Clinical Trial Pipeline

In certain autoimmune diseases, pathogenic B cells secrete autoantibodies, or antibodies that mistakenly target healthy host proteins, which are responsible for causing disease.

Advancing an Innovative Collection of Autoimmune Therapy Candidates

We are developing a portfolio of engineered T cell therapy candidates to treat B cell-mediated autoimmune diseases. Our lead Chimeric Antigen Receptor T cell for Autoimmunity (CARTA) candidate, CABA-201, is being developed for severe autoimmune diseases.

Our lead Chimeric AutoAntibody Receptor T (CAART) cell therapy product candidate, DSG3-CAART, is being evaluated in the DesCAARTes™ trial, targeting B cells that cause mucosal pemphigus vulgaris (mPV), a life-threatening autoimmune blistering disease affecting the mucous membranes. MuSK-CAART is advancing to the clinic. We also have several preclinical and discovery-stage targeted cell therapy candidates under development, all created with the vision of improving the lives of patients with B cell-mediated autoimmune diseases.

Our Pipeline

CABA ^™ Platform	Indication	Program	Discovery	Preclinical	Phase 1	Phase 2/3
CARTA - Chimeric Antigen Receptor T cells for Autoimmunity	Multiple Undisclosed Indications	CABA-201 4-1BB CD19-CAR T	Discovery complete	Preclinical in progress	Phase 1 not started	Phase 2/3 not started
CAART¹ - Chimeric AutoAntibody Receptor T cells	Mucosal Pemphigus Vulgaris	DSG3-CAART	Discovery complete	Preclinical complete	Phase 1 in progress	Phase 2/3 not started
	MuSK Myasthenia Gravis	MuSK-CAART	Discovery complete	Preclinical complete	Phase 1 not started	Phase 2/3 not started
	PLA2R Membranous Nephropathy	PLA2R-CAART	Discovery complete	Preclinical in progress	Phase 1 not started	Phase 2/3 not started
	Mucocutaneous Pemphigus Vulgaris	DSG3/1-CAART	Discovery in progress	Preclinical not started	Phase 1 not started	Phase 2/3 not started

¹Additional CAART disease targets in discovery stage include two undisclosed indications.

DSG3-CAART for Mucosal Pemphigus Vulgaris

Our lead product candidate, DSG3-CAART, is an engineered T cell therapy targeted to the B cells that cause mucosal pemphigus vulgaris (mPV), a life-threatening autoimmune blistering disease that leads to severe erosion and compromise of mucous membranes. It is currently being evaluated in patients with mucosal pemphigus vulgaris in the DesCAARTes™ Phase 1 clinical trial.

Learn about DSG3-CAART for mPV

MuSK-CAART for MuSK Myasthenia Gravis

Muscle-specific Kinase Myasthenia Gravis (MuSK MG) is an autoimmune disease that leads to disabling muscle fatigue, motor impairment, and episodes of respiratory failure. We are developing MuSK-CAART to target the B cells that cause this disease.

Learn about MuSK-CAART for MuSK MG

PLA2R-CAART for PLA2R-Associated Membranous Nephropathy

Phospholipase A2 Receptor-Associated Membranous Nephropathy (PLA2R MN) is an autoantibody-mediated glomerular disease that causes nephrotic syndrome and may lead to kidney failure. We are engineering PLA2R-CAART to selectively deplete the B cells that produce these disease-causing autoantibodies.

Learn about PLA2R-CAART for PLA2R MN

CABA-201 for B Cell-Mediated Autoimmune Diseases

We are developing CABA-201, a fully human CD19 chimeric antigen receptor (CAR) T cell therapy containing a 4-1BB co-stimulatory domain, for B cell-mediated autoimmune diseases with high unmet need.

Learn about CABA-201

DSG3/1-CAART for Mucocutaneous Pemphigus Vulgaris

We are developing DSG3/1-CAART to target mucocutaneous pemphigus vulgaris (mcPV), a painful blistering disease that affects both the skin and mucous membranes and predisposes patients to potentially life-threatening infections.

Learn about DSG3/1-CAART for mcPV

Pipeline