Science that Strikes the Right Chord

Composing Cell Therapy Approaches in Autoimmunity

Building on the established success of T cell therapies in cancer and recent compelling clinical data on CD19-CAR T in autoimmunity, we are developing Chimeric Antigen Receptor T cells for Autoimmunity (CARTA) to address a broad range of autoimmune diseases. CABA-201, our lead CARTA candidate, is an investigational fully human CD19 chimeric antigen receptor (CAR) T cell therapy with a 4-1BB co-stimulatory domain currently under development for systemic lupus erythematosus (SLE), myositis, systemic sclerosis, and generalized myasthenia gravis as well as other autoimmune diseases with high unmet need.