The Final Act for Autoimmune Disease
What if autoimmune diseases could be cured with a one-time treatment? At Cabaletta Bio, we believe it is possible.
On a proven foundation of CAR T technology and an established track record of clinical operational excellence in cell therapy in autoimmunity since 2018, we are developing innovative engineered T cell therapies for patients with autoimmune diseases. Our proprietary Cabaletta Approach to B cell Ablation (CABA®) platform is designed to provide deep, durable, and potentially curative responses with one-time administration across many autoimmune diseases, and it encompasses two approaches.
The Chimeric Antigen Receptor T cells for Autoimmunity (CARTA) approach is designed to transiently, but fully, eliminate B cells, thus potentially enabling an “immune system reset.” Our lead CARTA candidate, CABA-201, is a fully human CD19-CAR T cell product candidate being developed in autoimmune diseases with high unmet need, including systemic lupus erythematosus, myositis, systemic sclerosis, and generalized myasthenia gravis.
Cabaletta’s initial Chimeric AutoAntibody Receptor T (CAART) cell approach is designed to eliminate only disease-causing B cells. The DesCAARTes™ and MusCAARTes™ trials are underway in patients with mucosal-dominant pemphigus vulgaris and MuSK myasthenia gravis, respectively.
To harness the immune system through innovative cell and gene therapies to deliver accessible cures for patients.