Our RESETTM clinical trials with rese-cel (investigational CD19-CAR T cell therapy) in lupus, myositis, systemic sclerosis, and pemphigus vulgaris are now recruiting.

Join Our Crew

Senior Research Associate or Associate Scientist, Translational Medicine

On-Site/Philadelphia, PA

About the Position

Reporting to the Senior Scientist, Translational Medicine we are seeking an experienced, motivated, detail-oriented, and highly skilled Senior Research Associate/Associate Scientist within our Translational Medicine team.

Under scientific and technical supervision, the individual will be primarily responsible for developing and performing autoantibody evaluation assays (MSD, Luminex, ELISA) assays and other molecular based assays such as dPCR. As part of the Translational Medicine team, the individual must be able to perform qualified assays on clinical trial participant materials, adhering to internal compliance standards.

Responsibilities Include

  • With guidance from a Senior Scientist, Translational Medicine, perform assays on clinical samples and potentially pre-clinical samples.
  • Perform qualified or validated molecular-based assays (Luminex, dPCR, MSD, ELISA, etc.) on clinical samples to inform on cell product persistence and efficacy in humans.
  • Participate in generating, qualifying, and validating GLP-like assays and contribute to the development of corresponding SOPs.
  • Interface heavily with the electronic lab notebook (eLN) system and sample management system; accurately capture data in a timely manner, ensuring data integrity and protocol compliance using an eLN.
  • Maintain GDP-compliant and detailed records for clinical sample lifecycle, including receipt, usage, inventory, and related documentation.
  • Assist with clinical sample accessioning while maintaining close attention to metadata entry and accuracy.
  • Gain opportunities to learn and perform cell-based assays, such as flow cytometry and cell killing assays.
  • Manage multiple internal projects and workstreams simultaneously.
  • Perform laboratory-associated tasks in accordance with GLP and Cabaletta Bio laboratory safety policies and SOPs.
  • Support general maintenance of laboratory space and contribute to weekly laboratory activities.

Required Qualifications

  • MS degree in Biology, Immunology, Engineering, or a related field, or a Bachelor’s degree with 2+ years of experience in an academic laboratory or the biotechnology industry is required.
  • Experience with molecular-based assays such as ELISA, MSD, Luminex, and/or dPCR platforms.
  • Significant laboratory experience, including aseptic technique, mammalian cell culture, and DNA extraction.
  • Ability to follow SOPs and adhere to good documentation practices.
  • Highly organized and efficient, with the ability to work independently. Strong problem-solving skills preferred.
  • Ability to communicate clearly and effectively, both verbally and in writing.
  • Desire to be part of a growing organization that uses cutting-edge science.
  • Strong team orientation and passion for continuous self-development.
  • Comfortable working in a fast-paced small company environment and able to adjust workload based on changing priorities.

Preferred Qualifications:

  • Experience in protocol design, qualification, and SOP generation.
  • Experience with qPCR/dPCR platforms.
  • Experience with autoantibody evaluation assays.
  • Experience with clinical sample handling and inventory management is strongly preferred.
  • Experience troubleshooting, qualifying, or validating molecular-based assays.
  • Experience in the biotechnology industry or in a startup industrial setting.
  • Previous experience with GLP/GCP and ICH regulations.
  • Prior experience using an electronic laboratory notebook system; involvement in system development is a plus.

Apply For This Job

How to Apply

Please click the link at the bottom of the posting to submit an application.

Benefits

Our most important asset is our people and we offer competitive benefits including health and retirement, PTO, and stock option plans.

Equal Opportunity Employer

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.