Our RESETTM clinical trials with rese-cel (investigational CD19-CAR T cell therapy) in lupus, myositis, systemic sclerosis, and pemphigus vulgaris are now recruiting.

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Senior Director, HR Operations

About the Position

The Senior Director, HR Operations is a strategic and execution focused leader responsible for building and scaling a modern, data driven HR infrastructure that enables organizational growth, operational excellence, and an exceptional employee experience.

Reporting into the CHRO, this role will lead HR technology, global HR operations, compliance, and people analytics, while also serving as a trusted HR Business Partner for a few key business leaders. The role will partner closely with Finance, Legal, and Business leadership to ensure that HR processes, systems, and insights are efficient, scalable, compliant, and aligned to business priorities, particularly in a dynamic, high growth environment.

The ideal candidate brings a track record of implementing HR systems, automating operations, leveraging analytics for decision making, and partnering with executive leadership, along with experience supporting compensation and benefits programs.

Responsibilities Include

HR Operations and Technology

  • Lead and optimize global HR operations across employee lifecycle processes (hire to retire), ensuring efficiency, scalability, and a strong employee experience.
  • Design and implement standardized workflows, policies, and service delivery models to support growth while driving continuous improvement, reducing manual processes, and increasing operational effectiveness.
  • Own the implementation and optimization of HR systems (HCM, ATS, performance management tools, etc.), including integration and migration from a legacy PEO.
  • Partner with IT and business stakeholders to deliver scalable, user-centric solutions.
  • Drive adoption of new systems, processes, and programs with high engagement and minimal disruption.
  • Leverage AI, automation, and digital tools to enhance HR service delivery, insights, and employee engagement.

People Analytics and Insights

  • Establish and track metrics such as time to fill, productivity, retention, and diversity goals, providing real-time visibility into headcount, attrition, engagement, performance, and hiring metrics.
  • Translate data into actionable insights that inform workforce planning, organizational design, and business decisions.
  • Support compensation planning cycles (merit, bonus, equity) and market benchmarking and job architecture.
  • Contribute to the design and administration of competitive, scalable benefits programs.

HR Business Partnering

  • Serve as an HR partner to designated business leaders, providing guidance on organizational design, workforce planning, and talent and performance management.
  • Support leaders with data-driven insights and pragmatic solutions that balance speed, quality, and culture.
  • Act as a trusted advisor during periods of growth, transformation, or change, and lead operational readiness for rapid growth and organizational changes.
  • Support culture evolution through scalable HR practices that reinforce company values and performance expectations.

Required Qualifications

  • Bachelor’s degree required; advanced degree (MHRM, MBA, or related) preferred.
  • 15+ years of progressive HR experience, with a focus in HR Operations and people analytics.
  • Demonstrated success leading HR technology implementations and transformations.
  • Experience building or scaling HR infrastructure in high-growth or dynamic environments (biotech, tech, or similar industries preferred).
  • Strong working knowledge of global HR compliance and employment practices.
  • Experience supporting compensation processes and benefits programs.
  • Track record of partnering with executive leaders and influencing decisions.
  • High level of judgment, adaptability, and resilience in fast-paced environments.
  • Exceptional communication and stakeholder management skills.
  • Ability to operate effectively in a fast-paced, collaborative, and evolving environment.


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How to Apply

Please click the link at the bottom of the posting to submit an application.

Benefits

Our most important asset is our people and we offer competitive benefits including health and retirement, PTO, and stock option plans.

Equal Opportunity Employer

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.