Our RESETTM clinical trials with rese-cel (investigational CD19-CAR T cell therapy) in lupus, myositis, systemic sclerosis, myasthenia gravis, and pemphigus vulgaris are now recruiting.

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Senior Director, New Product Planning

About the Position

This role can be based out of our Philadelphia, PA headquarters or hybrid.

Reporting to the Chief Business Officer, the Senior Director, New Product Planning at Cabaletta Bio will serve as the product-strategy lead across the development lifecycle, generating and translating deep market understanding into actionable product decisions. This role is responsible for defining and maintaining target product profiles, generating market insights, partnering with commercial on customer understanding and bottom-up forecasting pre-launch while ensuring that development, regulatory, and commercial strategies are aligned to deliver differentiated, clinically meaningful therapies that meet unmet patient and provider needs.

Responsibilities Include

  • Lead product-focused new product planning across early- and late-stage programs, including definition and evolution of Target Product Profiles (TPPs).
  • Design and oversee qualitative and quantitative market research to inform product design, indication prioritization, and differentiation strategy.
  • Translate customer, payer, and market insights into clear product requirements and strategic recommendations for development teams.
  • Partner closely with Clinical Development, Regulatory, and Medical Affairs to ensure development plans reflect real-world market needs and constraints.
  • Assess competitive landscapes, evolving standards of care, and emerging data to guide product positioning and lifecycle planning.
  • Develop product narratives that articulate clinical value, unmet need, and differentiation for internal decision-making and external stakeholders.
  • Support portfolio prioritization through product-level assessments, scenario analyses, and value framing.
  • Prepare and present product strategy updates to governance forums and senior leadership.
  • Establish best practices, tools, and frameworks for product planning and insight generation across the portfolio.

Required Qualifications

  • Bachelor’s degree in life sciences, business, marketing, or a related field; advanced degree (MBA, PharmD, MS) preferred.
  • 10+ years of experience in product strategy, new product planning, marketing, or commercial insight roles within biopharmaceuticals.
  • Demonstrated expertise in market research methodologies, insight generation, and translating findings into product strategy.
  • Strong understanding of the drug development lifecycle and how product decisions influence clinical, regulatory, and commercial outcomes.
  • Excellent communication skills with the ability to synthesize complex information into clear, decision-oriented recommendations.
  • Proven ability to influence cross-functional teams without direct authority.
  • Strong team orientation and passion for continuous self-development.
  • Experience supporting development-stage or pre-launch assets, including early asset strategy and indication expansion, highly preferred.
  • Background in rare disease, autoimmune, cell therapy, or other specialty therapeutic areas, highly preferred.
  • Hands-on experience working with external vendors for market research, advisory boards, and primary research, highly preferred.
  • Comfort operating in a high-growth, science-driven biotechnology environment, highly preferred.

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How to Apply

Please click the link at the bottom of the posting to submit an application.

Benefits

Our most important asset is our people and we offer competitive benefits including health and retirement, PTO, and stock option plans.

Equal Opportunity Employer

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.