Our RESETTM clinical trials with CABA-201 (investigational CD19-CAR T cell therapy) in lupus, myositis, systemic sclerosis, myasthenia gravis, and pemphigus vulgaris are now recruiting.

Join Our Crew

Vice President and Head of Information Technology

About the Position

This role will be hybrid or based out of our Philadelphia, PA headquarters.

The Vice President and Head of Information Technology will be responsible for designing, implementing, and managing the company’s entire IT infrastructure and strategy. This role will lead the development of scalable, secure, and compliant systems that facilitate innovation and reliably support operational excellence across all functions. Reporting to the Chief Financial Officer, this hands-on leader will bring deep technical expertise, strong leadership skills, and a track record of building IT capabilities in a regulated life sciences environment. The role will very closely partner with commercial, manufacturing, finance, and HR leaders to launch the company’s lead product Rese-cel.

Responsibilities Include

Strategic Leadership

  • Develop and execute a forward-looking IT strategy aligned with business priorities and regulatory requirements.
  • Partner closely with executive leadership to identify and implement technology solutions that drive efficiency and innovation.
  • Build and lead a high-performing IT team, fostering a culture of service, agility, and continuous improvement.

Enterprise Infrastructure

  • Experience with building and integrating a global Cell and/or Gene product ordering platform across the patient journey in close partnership with relevant internal stakeholders
  • Architect and deploy scalable infrastructure across cloud, network, and on-premise environments.
  • Collaborate with functional leads to guide the selection and implementation of reliable and efficient enterprise systems (e.g., ERP, LIMS, QMS, HRIS, CRM) to support scientific, clinical, technical operations, commercial and corporate functions.
  • Ensure system interoperability, data integrity, and performance across the organization.

Security & Compliance

  • Establish and maintain robust cybersecurity frameworks and data protection protocols.
  • Ensure IT systems and practices comply with GxP, HIPAA, GDPR, and other relevant regulations, where applicable.
  • Lead IT audits, risk assessments, and incident response planning, maintaining clear traceability.

Operational Excellence

  • Provide responsive and proactive IT support to all departments, including R&D, clinical, regulatory, and finance.
  • Prioritize investments based on value, risk, and life cycle phase in alignment with corporate strategy
  • Manage IT budgets, vendors, and service level agreements.
  • Drive automation, analytics, and digital transformation, and AI initiatives to enhance productivity and scalability.
  • Develop, engage, and collaborate in change management practices for updates and changes

Required Qualifications

  • Bachelor’s or Master’s degree in Computer Science, Information Systems, or related field.
  • 10+ years of progressive IT leadership experience, with at least 3 years in biotech, pharma, or life sciences.
  • Proven success in building IT infrastructure and teams from the ground up in a high-growth environment with preference for direct experience in supporting autologous cell therapy launch and commercialization.
  • Expertise in SaaS and cloud platforms (e.g., AWS, Azure), cybersecurity, and enterprise applications.
  • Experience with GxP systems, 21 CFR Part 11, GAMP 5, EU Annex 9, ICH Q9 and other regulatory compliance systems in a commercial biotech or clinical setting.
  • Strong leadership, communication, and cross-functional collaboration skills with a client focused, partnering approach
  • Strong team orientation and passion for continuous self-development.

Apply For This Job

How to Apply

Please click the link at the bottom of the posting to submit an application.

Benefits

Our most important asset is our people and we offer competitive benefits including health and retirement, PTO, and stock option plans.

Equal Opportunity Employer

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.