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Senior Research Associate/Associate Scientist, Analytical Development

Philadelphia, PA

About the Position

Reporting to the Associate Principal Scientist, Analytical Development, this experienced and motivated Associate Scientist/Senior Research Associate will play a key role in the development of analytical methods and support activities of routine analytical testing and method qualification to support CARTA and CAART platforms for pre-clinical and clinical programs.  This position requires a highly skilled and experienced scientist with a background in biology and rich experience for method development, qualification, and troubleshooting.

Responsibilities Include

  • Assist to design and develop analytical methods for the characterization and release of lentiviral vectors and CAR-T / CAAR-T cells.
  • Assist to Identify and implement opportunities for analytical method improvement and participate optimization of existing analytical methods to enhance sensitivity and efficiency.
  • Perform method qualification studies in accordance with regulatory guidelines.
  • Conduct quality control assays to evaluate lentiviral vectors, CAR-T / CAAR-T cells and stability samples generated by internal groups and external partners.
  • Perform general lab and equipment maintenance duties.
  • Participate in technical troubleshooting and problem investigation.
  • Prepare, evaluate, and present data internally to cross functional teams.
  • Prepare detailed and accurate documentation of experimental procedures, results, and conclusions.
  • Stay current with advances in analytical techniques and industry trends.

Required Qualifications

  • Bachelor’s or master’s degree in biology or closely related discipline, and with 2-4 years of experience.
  • Proficient in aseptic technique for cell culture and cell-based assays.
  • Strong experience in analytic techniques, including flow cytometry, qPCR/dPCR, and ELISA etc.
  • Flexible to support various analytical activities and to learn new techniques outside of existing field of expertise.
  • Experience with analytical method development or quality control programs for lentiviral vector and CAR-T product preferred.
  • Ability to work independently and collaboratively in a fast-paced environment.
  • Highly organized and strong written and verbal communication skills.
  • Strong team orientation and passion for continuous self-development.
  • Strong laboratory documentation practice with high scientific integrity.
  • Familiarity with regulatory requirements and guidelines (FDA, ICH, etc.) for biopharmaceutical manufacturing.
  • Experience in industry or in a startup industrial setting is preferred.

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How to Apply

Please click the link at the bottom of the posting to submit an application.


Our most important asset is our people and we offer competitive benefits including health and retirement, PTO, and stock option plans.

Equal Opportunity Employer

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.