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Associate Scientist/Scientist, Analytical Development

Philadelphia, PA

About the Position

Reporting to the Director, Analytical Development, this experienced and motivated Associate Scientist/Scientist will support phase-appropriate activities of analytical assay development to cell manufacturing process development, lentiviral vector manufacture, and new gene transfer/gene editing methodologies, in order to advance pre-clinical and clinical programs under the CARTA strategy.

Responsibilities Include

  • Optimize and qualify analytical methods that utilize flow cytometry, qPCR/digital PCR, MSD, ELISA, or other technologies, as required to evaluate purity, identity, potency of in-process and final lentiviral vectors, CAR T cells and CAAR T cells.
  • Execute quality control assays to evaluate in-process and final lentiviral vectors, CAR T cells and CAAR T cells, as well as stability samples from in-house and external partners.
  • Assist to develop new analytical methods used to assess advanced gene transfer and gene editing modalities.
  • Assist to author analytical development report, assay validation report and other technical documents for technical correctness and regulatory compliance.
  • Be SME/trainer in analytics and participate in technical troubleshooting and problem investigation.
  • Prepare, evaluate, and present data internally to cross functional teams.

Required Qualifications

  • Bachelor or master’s degree in Biology or closely related discipline with 2-4 years of experience within a relevant industry.
  • Experience with analytical assay development or quality control programs for lentiviral vector and CAR-T product preferred.
  • Relevant hands-on experience with flow cytometry, qPCR, digital PCR and ELISA.
  • Must be highly organized and able to work independently.
  • Must be able to clearly communicate in writing, must have a desire to be part of a growing organization that uses cutting-edge science.
  • A high level of flexibility to support various other activities and ability to learn new techniques outside of existing field of expertise. 
  • Strong team orientation, science curiosity and passion for continuous self-development.
  • Strong laboratory documentation experience.
  • Familiar with GxP requirements of biopharmaceutical manufacturing.

How to Apply

Please email directly to submit an application.

Please include your CV along with the title of the position you are applying for.


Our most important asset is our people and we offer competitive benefits including health and retirement, PTO, and stock option plans.

Equal Opportunity Employer

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.