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Senior Research Associate/ Associate Scientist, Translational Medicine

Philadelphia, PA

About the Position

Reporting to the Scientist, Translational Medicine we are seeking an experienced, motivated, detail-oriented, and highly skilled Senior Research Associate/Associate Scientist within our Translational Medicine team.

Under scientific and technical supervision, the individual will be primarily responsible for performing cell killing assays on the incuCyte platform, flow cytometry and other cell-based assays on clinical samples that will provide data and insight on the safety and efficacy of Cabaletta’s clinical candidates. The candidate should be a highly motivated self-starter with well-established organizational skills who is excited to be a part of the biotechnology industry.

Responsibilities Include

  • With guidance from the Scientist, Translational Medicine, performing assays on clinical samples and potentially pre-clinical.
  • Performing qualified or validated cell-based assays (cell killing assays, etc.) on clinical samples to inform on cell product persistence and efficacy in humans.
  • Performing complex multi-color flow of manufactured product to evaluate key biomarker expression.
  • Opportunities to perform molecular based assays such as MSD, Luminex, etc.
  • Generating, qualifying, and validating GLP-like protocols and contributing to the development of corresponding SOPs.
  • Interfacing heavily with the electronic lab notebook system and sample management system; accurately capturing data in a timely manner, ensuring data integrity and protocol compliance using an electronic lab notebook (eLN).
  • Maintaining GDP-compliant and detailed records for clinical sample lifecycle (receipt, usage, inventory, etc.).
  • Managing multiple internal projects / workstreams simultaneously.
  • Performing lab associated tasks in accordance with GLP and Cabaletta Bio lab safety policies and SOPs.

Required Qualifications

  • MS degree in Biology, Immunology, Engineering or related field or Bachelor’s degree with 2+ years of experience in an academic laboratory or the biotechnology industry is required.
  • Experience with flow cytometry in some capacity; multi-colored flow panels are a plus.
  • Experience with clinical sample handling and inventory management is strongly recommended.
  • Significant lab experience including aseptic technique, mammalian cell culture, human tissue handling required, and plated cell-based assays.
  • Experience in protocol design, qualification, and SOP generation. Must be used to following SOPs and follow GDP.
  • Must be highly organized and efficient, able to work independently. Strong problem-solving skills are preferred.
  • Must be able to communicate clearly verbally and in writing.
  • Must have a desire to be part of a growing organization that uses cutting-edge science.
  • Strong team orientation and passion for continuous self-development.
  • Comfortable in a fast-paced small company environment and able to adjust workload based upon changing priorities.

Preferred Skills

  • Experience troubleshooting, qualifying or validating cell-based assays, preferably In a 96 well format.
  • Experience using the IncuCyte live cell imaging platform.
  • Experience using multi-color panels for flow cytometry.
  • Experience in the biotechnology industry or in a startup industrial setting.
  • Previous experience with GLP/GCP & ICH regulations.
  • Prior use of an electronic laboratory notebook system; involvement in system development is a plus.

How to Apply

Please email directly to submit an application.

Please include your CV along with the title of the position you are applying for.


Our most important asset is our people and we offer competitive benefits including health and retirement, PTO, and stock option plans.

Equal Opportunity Employer

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.