Annual report pursuant to Section 13 and 15(d)

Commitments and Contingencies - Additional Information (Details)

v3.22.4
Commitments and Contingencies - Additional Information (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Commitments and Contingencies [Line Items]    
Monthly fee included in minimum lease payment   $ 752
Research and development expense $ 39,300 32,494
Wuxi Agreement | WuXi Advanced Therapies    
Commitments and Contingencies [Line Items]    
Lease expiration period 2024-01  
Early termination fee $ 1,500  
Research Service Agreement | Children's Hospital of Philadelphia    
Commitments and Contingencies [Line Items]    
Research and development expense 166 $ 1,071
liability related to agreement $ 480