Quarterly report pursuant to Section 13 or 15(d)

Commitments and Contingencies - Additional Information (Details)

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Commitments and Contingencies - Additional Information (Details) - USD ($)
1 Months Ended 3 Months Ended 6 Months Ended
Feb. 28, 2022
Jan. 31, 2021
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Commitments and Contingencies [Line Items]            
Research and development expense     $ 9,514,000 $ 7,850,000 $ 18,684,000 $ 14,406,000
Loss related to litigation settlement accrued         $ 0  
Operating Lease Agreement            
Commitments and Contingencies [Line Items]            
Operating lease, description         The lease term commenced in May 2019 and was set to expire in July 2022.  
Lease commencement period         2019-05  
Lease expiration period 2025-06       2022-07  
Initial annual base rent $ 279,000       $ 261,000  
Percentage of annual increase of base rent 2.50%       2.00%  
Lease Amendment Period 35 months          
Rent expense     408 68,000 $ 578 136,000
Wuxi Agreement | WuXi Advanced Therapies            
Commitments and Contingencies [Line Items]            
Lease expiration period   2024-01        
Rent expense     375,000 120,000 685,000  
Monthly fee included in minimum lease payment   $ 125,000        
Early termination fee   $ 1,500,000        
Research Service Agreement | Children's Hospital of Philadelphia            
Commitments and Contingencies [Line Items]            
Research and development expense     0 $ 350,000 166,000 $ 572,000
Liability related to agreement     $ 480,000   $ 480,000