Quarterly report pursuant to Section 13 or 15(d)

Commitments and Contingencies - Additional Information (Details)

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Commitments and Contingencies - Additional Information (Details)
1 Months Ended 3 Months Ended 6 Months Ended
May 31, 2020
USD ($)
Jun. 30, 2020
USD ($)
Faculty
Jun. 30, 2019
USD ($)
Jun. 30, 2020
USD ($)
Faculty
Jun. 30, 2019
USD ($)
Dec. 31, 2019
USD ($)
Commitments and Contingencies [Line Items]            
Rent expense   $ 66,000 $ 43,000   $ 43,000  
Research and development expense   5,331,000 2,664,000 $ 9,951,000 5,425,000  
Manufacturing agreements, maximum amount committed   2,250,000   $ 2,250,000    
Operating Lease Agreement            
Commitments and Contingencies [Line Items]            
Operating lease, description       The lease term commenced in May 2019 and will expire in July 2022.    
Lease commencement period       2019-05    
Lease expiration period       2022-07    
Initial annual base rent       $ 261,000    
Percentage of annual increase of base rent       2.00%    
Rent expense       $ 133,000    
Research Service Agreement | Children's Hospital of Philadelphia            
Commitments and Contingencies [Line Items]            
Research and development expense   0 22,000 0 201,000  
Amounts due to agreement   0   0    
Penn Agreement            
Commitments and Contingencies [Line Items]            
Amounts due to agreement   0   0    
Obligation to be paid   2,000,000   $ 2,000,000    
Payment term       3 years    
Payment commencement date       2018-08    
License maintenance fee $ 33,000     $ 10,000    
Other amounts paid to agreement       0    
Total milestone payments       20,000,000    
Sponsored Research Agreements | Penn            
Commitments and Contingencies [Line Items]            
Research and development expense   733,000 711,000 1,336,000 1,421,000  
Obligation to be paid   $ 11,781,000   $ 11,781,000    
Number of faculty member | Faculty   2   2    
Funding term end date       2023-02    
Sponsored Research Agreements | Penn | Prepaid Expenses and Other Current Assets            
Commitments and Contingencies [Line Items]            
Advance payments   $ 1,673,000   $ 1,673,000   $ 1,588,000
Master Translational Research Services Agreement            
Commitments and Contingencies [Line Items]            
Research and development expense   1,027,000 617,000 1,738,000 1,684,000  
Maximum research and development expense incurred       1,510,000    
Subscription and Technology Transfer Agreement            
Commitments and Contingencies [Line Items]            
Expense related to agreement   $ 0 $ 0 $ 0 $ 0