Annual report pursuant to Section 13 and 15(d)

Commitments and Contingencies - Additional Information (Details)

v3.22.0.1
Commitments and Contingencies - Additional Information (Details) - USD ($)
1 Months Ended 3 Months Ended 12 Months Ended
Feb. 28, 2022
Jan. 31, 2021
Oct. 31, 2021
Dec. 31, 2021
Dec. 31, 2020
Commitments and Contingencies [Line Items]          
Research and development expense       $ 32,494,000 $ 21,376,000
Loss related to litigation settlement accrued       $ 0  
Operating Lease Agreement          
Commitments and Contingencies [Line Items]          
Operating lease, description       The lease term commenced in May 2019 and will expire in July 2022.  
Lease commencement period       2019-05  
Lease expiration period       2022-07  
Initial annual base rent       $ 261,000  
Percentage of annual increase of base rent       2.00%  
Rent expense       $ 272,000 266,000
Operating Lease Agreement | Subsequent Event          
Commitments and Contingencies [Line Items]          
Lease expiration period 2025-06        
Initial annual base rent $ 279,000        
Percentage of annual increase of base rent 2.50%        
Lease Amendment Period 35 months        
Wuxi Agreement | WuXi Advanced Therapies          
Commitments and Contingencies [Line Items]          
Lease expiration period       2024-01  
Rent expense       $ 480,000  
Monthly fee included in minimum lease payment   $ 125,000      
Early termination fee   $ 1,500,000      
Research Service Agreement | Children's Hospital of Philadelphia          
Commitments and Contingencies [Line Items]          
Research and development expense       1,071,000 $ 0
Accrued liability related to agreement       646,000  
Research Service Agreement | Children's Hospital of Philadelphia | Accrued and Other Current Liabilities          
Commitments and Contingencies [Line Items]          
Accrued liability related to agreement       166,000  
Agreement with Contract Manufacturing Organization          
Commitments and Contingencies [Line Items]          
Total cost     $ 1,620,000    
Expense related to agreement       1,310,000  
Agreement with Contract Manufacturing Organization | Accrued and Other Current Liabilities          
Commitments and Contingencies [Line Items]          
Accrued liability related to agreement       $ 827,000