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Senior Scientist/Associate Principal Scientist, Cellular Immunology

Philadelphia, PA

About the Position

We are seeking a highly experienced and innovative Senior Scientist/Associate Principal Scientist with expertise in preclinical development of allogeneic cell therapy, reporting to Head of Cellular and Molecular Immunology. As a key member of our research and development team, you will play a crucial role in the development and optimization of allogeneic cell therapies for various autoimmune diseases. This position offers an exciting opportunity to contribute to cutting-edge research and translation of allogeneic cell therapies into clinical applications.

If you are a highly motivated and accomplished scientist with a strong background in allogeneic cell therapy and preclinical research, we encourage you to apply for this challenging and impactful Senior Scientist/Associate Principal Scientist position. Join our dynamic team and contribute to the development of life-changing therapies that have the potential to make a significant impact in patient care.

Responsibilities Include

  • Lead and contribute to designing and executing preclinical studies to evaluate the safety, efficacy, and pharmacology of allogeneic cell therapies.
  • Develop and optimize in vitro assays and oversee in vivo assays to evaluate the functionality, potency, and characteristics of allogeneic cell therapy products.
  • Collaborate closely with cross-functional teams to define project strategies, timelines, and deliverables, and ensure alignment with overall development plans.
  • Apply deep scientific expertise in cellular immunotherapy and allogeneic cell engineering to design and implement innovative approaches for improving the therapeutic potential and functionality of allogeneic cell therapies.
  • Overtime, lead and manage a team of scientists and research associates, providing scientific guidance, mentorship, and fostering a collaborative and productive work environment.
  • Analyze and interpret complex experimental data, develop hypotheses, and make data-driven recommendations for advancing allogeneic cell therapy programs.
  • Contribute to the preparation of scientific publications, presentations, regulatory documents, and intellectual property filings.
  • Keep up to date with the latest scientific advancements, emerging technologies, and competitive landscape in the field of allogeneic cell therapy and contribute to the continuous improvement of research methodologies and techniques. 
  • Ensure compliance with relevant regulatory guidelines, quality standards, and ethical considerations in all preclinical activities.

Required Qualifications

  • Ph.D. in Immunology, Cell Biology, Molecular Biology, or a related field and 2 years of relevant experience. Post-doctoral experience in cellular immunotherapy or allogeneic cell therapy research is highly preferred.
  • Strong background in immunology and hands-on experience with immune cell-based assays with a focus on cell-based therapies.
  • Extensive experience in various molecular and cellular biology techniques, including gene editing, flow cytometry, immune functional assays.
  • Proficiency in designing and executing preclinical studies, including protocol development, data collection, analysis, and interpretation.
  • Excellent analytical, problem-solving, and data interpretation skills, with a track record of delivering high-quality results.
  • Strong written and verbal communication skills, with the demonstrated ability to work in a multidisciplinary team environment, with excellent communication and collaboration skills.
  • Prior experience with regulatory requirements for preclinical studies and an understanding of Good Laboratory Practices (GLP) is a plus.
  • Strong problem-solving skills, attention to detail, and the ability to adapt to evolving research priorities.
  • Strong team orientation and passion for continuous self-development.
  • Experience in industry or in ap industrial setting is preferred.

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How to Apply

Please click the link at the bottom of the posting to submit an application.


Our most important asset is our people and we offer competitive benefits including health and retirement, PTO, and stock option plans.

Equal Opportunity Employer

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.