Join Our Crew

Senior Director, Human Resources

Philadelphia, PA

About the Position

Reporting to the (part time) Chief HR Officer, this position leads the development, management and execution of HR strategies and processes to establish and grow a high performing organization, inclusive of organization development, staffing, compensation and benefits, performance management and team development. The incumbent of this role is expected to succeed the Chief HR Officer as the lead Human Resources executive, ultimately reporting directly to the CEO.

Responsibilities Include

  • Partner with the CHRO and leadership team to maintain and enhance a high performing organization. Provide individual coaching and team effectiveness guidance and support.
  • Partner with the CHRO and leadership team in sustaining and enhancing a successful, fun, team-oriented, performance-based culture and organization, (consistent with 2021 recognition as a Fortune Great Place to Work company). Become a trusted advisor on employee morale and organization health. 
  • Develop and maintain effective staffing and onboarding processes. Manage outsourced recruiting and search partners for most effective and efficient hiring.  Oversee and engage in interview and hiring process to ensure effective decisions and positive candidate experience. 
  • Continuously improve and execute annual objective setting, performance management, talent and compensation planning processes and assist management in the preparation and administration of same.
  • Monitor and optimize organization design (procedures, structures and systems).
  • Serve as a link between management and employees by handling questions, and helping resolve work related problems. Ensure maintenance of high integrity work environment with full compliance with US employment law. 
  • Review, endorse and/or make recommendations for headcount additions, promotions or reclassification.
  • Support CHRO in corporate governance and executive compensation matters.
  • Develop, interpret and apply HR specific and general company policies.
  • Administer HR systems as applicable, and safety and health programs.
  • Consult with General Counsel as appropriate on employment matters
  • Prepare and manage human resources budgets, inclusive of planning operating model changes required to support efficient operations with continued growth of company.

Required Qualifications

  • 10+ years of human resources experience required.
  • Biotech/Pharmaceutical industry experience highly preferred.
  • Small/start-up company experience preferred.
  • Undergraduate degree required; Master’s in Human Resources Management, Organizational Psychology or relevant field
  • Excellent interpersonal and communication skill required
  • Knowledge of and experience with the full spectrum of HR functions required, from compensation and policy matters to organization and culture development
  • Outstanding integrity and ethical conduct
  • Strong team orientation and passion for continuous self-development

How to Apply

Please email directly to submit an application.

Please include your CV along with the title of the position you are applying for.


Our most important asset is our people and we offer competitive benefits including health and retirement, PTO, and stock option plans.

Equal Opportunity Employer

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.

About Cabaletta Bio

Cabaletta Bio (NASDAQ: CABA) is focused on the discovery and development of T cell therapies for B cell-mediated autoimmune diseases. Our proprietary technology utilizes Chimeric AutoAntibody Receptor (CAAR) T cells that are designed to precisely bind and destroy only specific autoantibody-expressing B cells while sparing normal antibody-expressing B cells, which are essential for human health. Cabaletta’s Approach for selective B cell Ablation platform, called our CABA™ platform, has applicability across more than two dozen B cell-mediated autoimmune diseases that we have identified, reviewed and prioritized. CAAR T technology is based on the revolutionary Chimeric Antigen Receptor (CAR) T cell technology developed at the University of Pennsylvania that resulted in one of the first commercially-available CAR T cell products for the treatment of B cell malignancies. Cabaletta has an exclusive global licensing agreement and multiple sponsored research agreements with the University of Pennsylvania to develop CAAR T technology to treat B cell-mediated autoimmune diseases.

The Company’s lead product candidate, DSG3-CAART, received IND clearance from the FDA in September 2019, and initial safety data in clinical trials has been reported. DSG3-CAART is designed to be a potential treatment for patients with mucosal pemphigus vulgaris (mPV), which is a rare autoimmune blistering disorder that causes painful blisters and sores on mucous membranes leading to severe and sometimes debilitating and life-altering effects. Cabaletta Bio is also pursuing additional pipeline candidates for other B cell mediated disorders including MuSK Myasthenia Gravis (MG) with an IND planned for 2H 2021, mucocutaneous PV, PLA2R positive membranous nephropathy (PMN), and Factor VIII inhibitors.

Uniquely Differentiated. Rapid. Elegant.

At Cabaletta, we are driven by the shared mission of developing a new type of therapy, where patients’ own cells are used to fight disease. We are building a culture grounded in the knowledge that success in the Cabaletta mission lies in the hands of individuals across every aspect of the company. To nurture this, we make an active commitment to the well-being and continuous growth of each person who joins our team. In this way, we are not only working to improve the lives of patients, but of everyone involved. #CabalettaCrew