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Scientist, Analytical Development

Philadelphia, PA

About Cabaletta Bio

Cabaletta Bio is focused on the discovery and development of T cell therapies for B cell-mediated autoimmune diseases. Cabaletta’s therapeutic platform produces highly selective autologous Chimeric AutoAntibody Receptor (CAAR) T cells that are designed to precisely bind and destroy only specific autoantibody-producing B cells while sparing normal antibody-producing B cells, which are essential for human health. The platform is based on the revolutionary Chimeric Antigen Receptor (CAR) T cell technology developed at the University of Pennsylvania that resulted in one of the first commercially available CAR T cell products for the treatment of B cell malignancies. Cabaletta has an exclusive global licensing agreement and multiple sponsored research agreements with the University of Pennsylvania to develop the CAAR T technology to treat B cell-mediated autoimmune diseases. Cabaletta’s lead therapeutic program is a potential treatment for a prototypical B cell-mediated autoimmune disease, mucosal pemphigus vulgaris (mPV), which is a rare skin disorder that causes painful blisters and sores on mucous membranes leading to severe and sometimes debilitating and life-altering effects.

Our name – Cabaletta – is derived from the operatic term for the second part of an aria that is designed to highlight the technical expertise of the lead singer. While our company is not the first to develop chimeric T cells as therapies, we are the first to develop them in a way that leverages T cells to specifically eliminate only B cells that cause disease, while sparing healthy B cells. Utilizing the backbone of this core technology, we expect to advance our portfolio with a rapid and repetitive rhythm, similar to the rhythm that is typical of a cabaletta.

Uniquely Differentiated. Rapid. Elegant.

At Cabaletta, we are driven by the shared mission of developing a highly innovative and targeted T cell therapy, where patients’ cells can be used to provide deep, durable, and potentially curative clinical responses for their autoimmune diseases. We are building a culture grounded in the knowledge that success in the Cabaletta mission lies in the hands of individuals across every aspect of the company. To nurture this, we make an active commitment to the well-being and continuous growth of each person who joins our team. In this way, we are not only working to improve the lives of patients but of everyone involved. #CabalettaCrew

About the Position

Reporting to the Director, Analytical Development, this experienced and motivated Scientist will support phase-appropriate activities of analytical assays to CAAR-T manufacturing production, lentiviral vector production, new gene transfer/gene editing methodologies and clinical programs.

Responsibilities Include

  • Optimize, qualify, and validate analytical methods utilizing flow cytometry, qPCR/digital PCR, cytotoxicity, ELISA or other advanced technologies, as required to evaluate purity, identity, potency of lentiviral vectors and CAAR-T cells.
  • Execute quality control assays to analyze lentiviral vectors and CAAR-T cells manufactured by external partners.
  • Develop new analytical tests to assess advanced gene transfer and gene editing modalities.
  • Assist to author analytical development report, assay validation report and other technical documents for technical correctness and regulatory compliance.
  • Participate in technical troubleshooting and problem investigation.
  • Prepare, evaluate, and present data internally to cross functional teams.

Required Qualifications

  • Master’s degree in Biology or closely related discipline, and with 3-5 years of experience or Ph.D. with 1 + years of experience within a relevant industry
  • Relevant hands-on experience with flow cytometry, qPCR/ddPCR and ELISA.
  • Experience with analytical assay development or quality control programs for cell or gene therapy products, including lentiviral vectors or CAR-T products.
  • Must be highly organized and able to work independently.
  • Must be able to clearly communicate in writing, must have a desire to be part of a growing organization that uses cutting-edge science.
  • A high level of flexibility to support various other activities and ability to learn new techniques outside of existing field of expertise.
  • Strong team orientation, science curiosity and passion for continuous self-development.
  • Strong laboratory documentation experience.
  • Familiar with GLP/GMP requirements of biopharmaceutical manufacturing.

How to Apply

Please email directly to submit an application.

Please include your CV along with the title of the position you are applying for.


Our most important asset is our people and we offer competitive benefits including health and retirement, PTO, and stock option plans.

Equal Opportunity Employer

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.