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Scientist / Sr. Scientist, Preclinical

Philadelphia, PA

About Cabaletta Bio

Cabaletta Bio is focused on the discovery and development of T cell therapies for B cell-mediated autoimmune diseases. Cabaletta’s therapeutic platform produces highly selective autologous Chimeric AutoAntibody Receptor (CAAR) T cells that are designed to precisely bind and destroy only specific autoantibody-producing B cells while sparing normal antibody-producing B cells, which are essential for human health. The platform is based on the revolutionary Chimeric Antigen Receptor (CAR) T cell technology developed at the University of Pennsylvania that resulted in one of the first commercially available CAR T cell products for the treatment of B cell malignancies. Cabaletta has an exclusive global licensing agreement and multiple sponsored research agreements with the University of Pennsylvania to develop the CAAR T technology to treat B cell-mediated autoimmune diseases. Cabaletta’s lead therapeutic program is a potential treatment for a prototypical B cell-mediated autoimmune disease, mucosal pemphigus vulgaris (mPV), which is a rare skin disorder that causes painful blisters and sores on mucous membranes leading to severe and sometimes debilitating and life-altering effects.

Our name – Cabaletta – is derived from the operatic term for the second part of an aria that is designed to highlight the technical expertise of the lead singer. While our company is not the first to develop chimeric T cells as therapies, we are the first to develop them in a way that leverages T cells to specifically eliminate only B cells that cause disease, while sparing healthy B cells. Utilizing the backbone of this core technology, we expect to advance our portfolio with a rapid and repetitive rhythm, similar to the rhythm that is typical of a cabaletta.

Uniquely Differentiated. Rapid. Elegant.

At Cabaletta, we are driven by the shared mission of developing a highly innovative and targeted T cell therapy, where patients’ cells can be used to provide deep, durable, and potentially curative clinical responses for their autoimmune diseases. We are building a culture grounded in the knowledge that success in the Cabaletta mission lies in the hands of individuals across every aspect of the company. To nurture this, we make an active commitment to the well-being and continuous growth of each person who joins our team. In this way, we are not only working to improve the lives of patients but of everyone involved. #CabalettaCrew

About the Position

We are seeking an experienced, motivated, and highly skilled Scientist or Senior Scientist to join our Preclinical Research team. Under scientific and technical supervision, the candidate will perform various cell-based assays and other in vitro and ex vivo based assays to contribute to the discovery and development of novel therapeutics at Cabaletta. The position offers growth into additional areas such as translational research and molecular biology, immunology, and cell therapy. The position involves both technical and operational responsibilities.

Responsibilities Include

  • Design, develop, and optimize complement assays as needed.
  • Perform and optimize cytotoxicity and flow cytometry assays as needed.
  • Perform and validate ELISpot, ELISA, or other assays as needed.
  • Maintain and expand, bank, and manage various cell lines.
  • Manage multiple internal projects for Translational, Analytical, and Manufacturing Sciences and collaborate with external sources.
  • Actively contribute to process improvements and the implementation of new technologies.
  • Perform lab associated tasks in accordance with cGLP and Cabaletta Bio lab safety policies.
  • Maintain accurate and well-organized records and electronic laboratory notebook.

Required Qualifications

  • B.S. with a minimum 10+ years or M.S. in Biology (or related discipline) or higher with a minimum of 5+ years of cellular immunology or complement biology experience, or a Ph.D. with 2+ years of experience in a complement system focused lab will be considered.
  • Significant lab experience and expertise in complement biology and assays required.
  • General lab skills including sterile techniques and human tissue handling required.
  • Must have prior experience and be highly skilled at mammalian cell culture (aseptic techniques).
  • Experience in primary cell culture and ELISpot highly desirable.
  • Experience in cytotoxicity assays (such as IncuCyte, xCELLigence, 51Cr or luciferase-based assays) and flow cytometry.
  • Must be highly organized and able to work independently.
  • Must be able to clearly communicate in writing, must have a desire to be part of a growing organization that uses cutting-edge science.
  • A high level of flexibility to support various other activities the ability to learn new techniques outside of existing field of expertise.
  • Strong team orientation and passion for continuous self-development.
  • Experience in biotechnology industry or in a startup industrial setting is preferred.

How to Apply

Please email directly to submit an application.

Please include your CV along with the title of the position you are applying for.


Our most important asset is our people and we offer competitive benefits including health and retirement, PTO, and stock option plans.

Equal Opportunity Employer

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.